Introduction
What Tolvat is used for?
- Tolvat is used to treat a disease called “autosomal dominant polycystic kidney disease” (ADPKD)
Warning & Precautions
Talk to Doctor
Talk to your doctor before you take this medicine, if you:
- Are allergic to this medicine
- Suffer from kidney or liver disease
- Have an enlarged prostate
- Suffer from too high or too low blood sodium
- Have diabetes
- Have been told you have high levels of a chemical called uric acid in your blood
Pregnancy & Breast Feeding
- Do not take this medicine if you are pregnant or breast-feeding
- If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
Children & Adolescents
- Tolvat has not been studied in children and adolescents (under age 18) and its use is therefore not recommended in these age groups
Driving & Using Machines
- Some people may feel dizzy, weak or tired after being given Tolvat . If this happens to you, do not drive or use any tools or machines
Interactions
Tell your doctor if you are taking,
- Ketoconazole, clarithromycin used to treat certain infections
- Digoxin a medicine for the treatment of irregular heart beat and heart failure
- Dabigatran medicine used to thin the blood
- Rosuvastatin or pitavastatin medicine used to lower blood cholesterol
- Methotrexate medicine used to treat cancer, arthritis
- Sulfasalazine medicine used to treat inflammatory bowel disease or rheumatoid arthritis
- Metformin medicine used for treatment of diabetes
- Phenytoin or carbamazepine medicine used for the treatment of epilepsy
- St.John’s wort herbal medicinal product for the relief of slightly low mood and mild anxiety
- Diuretics medicine used to increase your urine production
- Desmopressin medicine used to increase blood clotting factors or to control urine output or bedwetting
How to Use
- Always take this medicine exactly as your doctor has told you
- Swallow the tablet with a glass of water
- The morning dose is to be taken at least 30 minutes before the morning meal. The second daily dose can be taken with or without food
- Tolvat 15 Tablet treats low sodium levels in the blood.
- It also improves urine flow without causing the body to lose too much sodium as you urinate.
- Take it at the same time everyday. Take it according to the dose and duration prescribed by your doctor.
- To avoid dehydration, it is best to drink something as soon as you feel thirsty, but avoid alcoholic drinks.
- Do not take Tolvat 15 Tablet if you are unable to urinate, if you are unable to tell when you are thirsty, or if you are severely dehydrated.
- You will need to be in a hospital under observation any time you start or restart treatment with Tolvat 15 Tablet.
- Inform your doctor if you notice problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, or mood changes.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
If you take more Tolvat
- If you have taken more tablets than your prescribed dose, drink plenty of water and contact your doctor or your local hospital immediately
If you forget to take Tolvat
- If you forget to take your medicine you should take the dose as soon as you remember on the same day
- If you do not take your tablets on one day, take your normal dose on the next day. Do not take a double dose to make up for forgotten individual doses
If you stop taking Tolvat
- Do not stop taking Tolvat without your doctor advice
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them
Serious
- Difficult to urinate
- Swelling of the face, lips or tongue, itching, generalised rash or severe wheezing or breathlessness
- Worsening of liver problems
Common
- Dehydration
- High levels of sodium, uric acid and blood sugar
- Decreased appetite or stomach upset
- Difficulty sleeping
- Shortness of breath
- Heartburn
- Liver function abnormal
- Rash
- Muscle spasms or general weakness
- Raised levels of liver enzymes in the blood
- Weight loss
- Headache
- Dizziness
- Dry mouth
- Fatigue
Uncommon
- Increase of bilirubin (a substance that can cause yellowing of skin or eyes) in the blood
More Information Additional Information
What is Autosomal dominant polycystic kidney disease” (ADPKD)?
This disease causes growth of fluid-filled cysts in the kidneys which put pressure on surrounding tissues and reduce kidney function, possibly leading to kidney failure.
Tolvat may cause your liver to not work properly. Therefore, please inform your doctor immediately if you have signs that could indicate potential liver problems such as:
- Nausea, vomiting, fever
- Tiredness
- Loss of appetite
- Pain in the abdomen
- Dark urine
- Jaundice (yellowing of skin or eyes)
- Itching of your skin
- Flu-like syndrome (joint and muscle pain with fever)
During treatment with Tolvat , your doctor will arrange monthly blood tests to check for changes in your liver function
Storage
- Keep this medicine out of reach of children
- Store at room temperature (15-25°C)
- Do not use this medicine after the expiry date
FAQs
Q. What is the most important information I need to be aware of while taking Tolvat ?
Tolvat may cause the level of sodium in your blood to increase too quickly. This quick increase in sodium levels [osmotic demyelination syndrome (ODS)] may cause serious nerve damage, which can further cause coma and even death. The symptoms of ODS could be trouble in speaking, trouble in swallowing or a feeling of food or liquid getting stuck while swallowing, drowsiness, confusion, mood changes, fits, trouble controlling body movement (involuntary movement) and weakness in muscles of the arms and legs.
Q. For how long do I need to take Tolvat ?
Tolvat is used for correction of sodium levels in blood. Though the dose and duration are prescribed by the doctor, Tolvat should not be taken for more than 30 days. Once the sodium levels return to normal, it can be stopped after talking to the doctor.
Q. Does Tolvat affect the sugar levels in blood?
Yes, Tolvat may increase the blood sugar levels. Therefore, patients with diabetes mellitus need to be extra careful while taking Tolvat and should keep a check on blood sugar levels regularly.
Q. Who should not take Tolvat ?
You should not take Tolvat if you have low sodium levels, cannot replace fluids by drinking or if you cannot tell when you are thirsty, dizzy or feeling faint or if your kidneys are not working properly because of excessive loss of fluids. You should also avoid Tolvat if your body is not able to make urine, you are allergic to Tolvat or if you are on certain medicines which interfere with the working of Tolvat .
Q. Can I have grapefruit juice while taking Tolvat ?
No, you should not take grapefruit or grapefruit juice while on Tolvat . The reason being, grapefruit or grapefruit juice may increase the levels of Tolvat in your blood and your sodium levels may rise too quickly.
Q. What will happen if I take excess of Tolvat ?
You may need urgent medical attention. Call your doctor or seek emergency service at a nearby hospital. Symptoms of taking too much Tolvaptan may include thirst, dry and flaky skin, sunken eyes, rapid heartbeat, rapid and shallow breathing, very low blood pressure, passing more urine than normal and fainting.
Tolvat may cause the level of sodium in your blood to increase too quickly. This quick increase in sodium levels [osmotic demyelination syndrome (ODS)] may cause serious nerve damage, which can further cause coma and even death. The symptoms of ODS could be trouble in speaking, trouble in swallowing or a feeling of food or liquid getting stuck while swallowing, drowsiness, confusion, mood changes, fits, trouble controlling body movement (involuntary movement) and weakness in muscles of the arms and legs.
Q. For how long do I need to take Tolvat ?
Tolvat is used for correction of sodium levels in blood. Though the dose and duration are prescribed by the doctor, Tolvat should not be taken for more than 30 days. Once the sodium levels return to normal, it can be stopped after talking to the doctor.
Q. Does Tolvat affect the sugar levels in blood?
Yes, Tolvat may increase the blood sugar levels. Therefore, patients with diabetes mellitus need to be extra careful while taking Tolvat and should keep a check on blood sugar levels regularly.
Q. Who should not take Tolvat ?
You should not take Tolvat if you have low sodium levels, cannot replace fluids by drinking or if you cannot tell when you are thirsty, dizzy or feeling faint or if your kidneys are not working properly because of excessive loss of fluids. You should also avoid Tolvat if your body is not able to make urine, you are allergic to Tolvat or if you are on certain medicines which interfere with the working of Tolvat .
Q. Can I have grapefruit juice while taking Tolvat ?
No, you should not take grapefruit or grapefruit juice while on Tolvat . The reason being, grapefruit or grapefruit juice may increase the levels of Tolvat in your blood and your sodium levels may rise too quickly.
Q. What will happen if I take excess of Tolvat ?
You may need urgent medical attention. Call your doctor or seek emergency service at a nearby hospital. Symptoms of taking too much Tolvaptan may include thirst, dry and flaky skin, sunken eyes, rapid heartbeat, rapid and shallow breathing, very low blood pressure, passing more urine than normal and fainting.
Disclaimer:The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
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